The stations are staffed by approximately 300 volunteer firefighters and supplemented by 24 career firefighters who are stationed at the busiest stations in the county. They respond to medical emergencies, fires, automobile accidents, and rescue situations.

All districts are staffed at a minimum of Emergency Medical Technician – Basic level, while most are recognized at the Emergency Medical Technician – Intermediate level. The Doña Ana County Fire and Rescue Services Department has a Hazardous Materials Response Team equipped with specialized testing, sampling, and decontamination equipment.